IN VITRO ACTIVITATEA ANTICANCERIGENĂ A (CLORO(N-FENIL-N'-[(PIRIDIN-2-IL)METILIDEN] CARBAMOHIDRAZONTIOLATO) (4-AMINOBENZEN-1-SULFONAMID)-CUPRU)

Olga GARBUZ

Abstract


Acest studiu a avut ca scop studierea activității antiproliferative a complexului (cloro(N-fenil-N'-[(piridin-2-il)me­ti­li­den]carbamohidrazontiolato)(4-aminobenzen-1-sulfonamid)-cupru) pe linii de celule cancerigene. S-a stabilit că com­ple­xul investigat cu cupru (II) prezintă cea mai mare activitate anticancerigenă împotriva celulelor liniilor MeW-164, HeLa, BxPC-3 și RD cu valori IC50 de 1,0±0,2, 0,4±0,04, 1,7±0,2, 1,3±0,3, respectiv. Studiul comparativ al compusului tes­tat cu DOXO în ceea ce privește liniile de celule cancerigene a arătat că complexul testat de cupru (II) prezintă o activitate inhibitoare mai puternică asupra proliferării celulelor cancerigene decât doxorubicina și cisplatina.


Keywords


complex mixt-ligand, doxorubicină, cisplatină, activitate anticancerigenă, linii de celule cancerigene

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References


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