Tatiana ERHAN, Olga GARBUZ, Aurelian GULEA


În lucrare este descrisă sinteza și activitatea antiproliferativă a 6 tiourei și a 6 tiosemicarbazide. Puritatea și identi­tatea compușilor obținuți a fost confirmată cu ajutorul spectroscopiei 1H și 13C RMN, IR, cromatografiei pe strat subțire CSS și al temperaturii de topire. Toate substanțele sintetizate au fost testate in vitro, pentru activitatea antiproliferativă pe liniile celulare umane de cancer, și anume: carcinom cervical (HeLa), carcinom pancreatic (BxPc-3), rhabdomiosarcomă (RD) și celule sănătoase de MDCK. S-a urmărit studiul relației structură-activitate.


The present paper describes the synthesis of 6 new thiosemicarbazides and 6 thioureas. The identity and purity of obtained organic compounds was proved by chromatography TSS, melting points, as well as by 13C and 1H NMR, IR spectra. The synthesized substances were tested, in vitro for the antiproliferative activity on cancer and normal cells of: HeLa (cervical cancer) cells, BxPc-3 (pancreatic cancer) cells, RD (rhabdomyosarcoma) cells and on normal MDCK cells. Structure-activity relationships were carried out.


N (4)-n-dimethylphenyl-3-thiosemicarbazide, N'-(n-dimethylphenyl)-N,N-dimethylthiourea, antiproliferative activity, HeLa, BxPc-3, RD, MDCK.

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